The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice
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چکیده
منابع مشابه
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.
A variety of neurotransmitters, gastrointestinal hormones, and metabolic signals are known to potentiate insulin secretion through GPCRs. We show here that beta cell-specific inactivation of the genes encoding the G protein alpha-subunits Galphaq and Galpha11 resulted in impaired glucose tolerance and insulin secretion in mice. Interestingly, the defects observed in Galphaq/Galpha11-deficient b...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2010
ISSN: 0021-9738
DOI: 10.1172/jci41541